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Beyer, Eric C.

One or more keywords matched the following properties of Beyer, Eric C.

Property	Value
keywords	Sickle Cell Disease
overview	Professor of Pediatrics Section of Hematology/Oncology and Stem Cell Transplantation
overview	Dr. Beyer is a physician scientist who practices pediatric hematology/oncology and has a broad background in basic laboratory and translational research. His laboratory has spent more nearly 30 years investigating intercellular communication (as mediated by the channels contained within gap junctions) and how its disruptions contribute to disease. These studies encompass basic investigations including identification and cloning of the subunit proteins, characterization of structure-function physiological relationships, determination of pathways of biosynthesis and degradation. Dr. Beyer's laboratory has also been pursuing translational examinations of the roles of these proteins in diseases including cataracts, deafness, arrhythmias, cancer, and premature labor. The group has spent many years studying the connexins expressed in the eye lens. They are elucidating the process of cataract development by studying mouse and cell culture models that mimic the pathologies seen in human families with connexin mutants and inherited cataracts. Dr. Beyer has investigated the roles of cardiac connexins in normal cardiac conduction and in the pathogenesis of arrhythmias. He is studying the roles of circulating extracellular vesicles in the vascular pathologies that underlie the crises of patients with sickle cell disease. He has mentored many students and post-doctoral fellows within his laboratory.

One or more keywords matched the following items that are connected to Beyer, Eric C.

Item Type	Name
Concept	Avian Sarcoma Viruses
Concept	Sodium-Potassium-Exchanging ATPase
Concept	Alleles
Concept	Amino Acid Sequence
Concept	Carbohydrate Sequence
Concept	Anastomosis, Surgical
Concept	Computer Simulation
Concept	Antibody Specificity
Concept	Base Sequence
Concept	Binding Sites
Concept	Cardiovascular System
Concept	Death, Sudden
Concept	Cardiac Surgical Procedures
Concept	Extracellular Space
Concept	Cross-Sectional Studies
Concept	Muscle, Smooth
Concept	Genes, Dominant
Concept	Genes
Concept	Immune Sera
Concept	Mice, Inbred Strains
Concept	Molecular Sequence Data
Concept	Muscle, Smooth, Vascular
Concept	Nervous System Diseases
Concept	Nervous System Physiological Phenomena
Concept	Salivary Glands
Concept	Spermine
Concept	Protein Synthesis Inhibitors
Concept	Receptors, Cell Surface
Concept	Sequence Homology, Nucleic Acid
Concept	Species Specificity
Concept	Cohort Studies
Concept	Sinoatrial Node
Concept	Sodium
Concept	Solubility
Concept	Swine
Concept	Sheep
Concept	Skin
Concept	Sulfates
Concept	Stomach
Concept	Genome
Concept	Sequence Homology, Amino Acid
Concept	Vena Cava, Superior
Concept	Gene Library
Concept	Chromosome Segregation
Concept	Electrophoretic Mobility Shift Assay
Concept	Second Messenger Systems
Concept	Rats, Sprague-Dawley
Concept	Mutagenesis, Site-Directed
Concept	Sequence Alignment
Concept	Lysosomal Storage Diseases
Concept	Drug Delivery Systems
Concept	Case-Control Studies
Concept	In Situ Hybridization
Concept	Sequence Analysis, DNA
Concept	Protein Structure, Tertiary
Concept	Sequence Deletion
Concept	HSP70 Heat-Shock Proteins
Concept	Oxidative Stress
Concept	src-Family Kinases
Concept	Transgenes
Concept	Reactive Oxygen Species
Concept	In Situ Hybridization, Fluorescence
Concept	Protein Structure, Secondary
Concept	Endoplasmic Reticulum Stress
Concept	Amino Acid Substitution
Concept	Somites
Concept	Rats, Inbred Strains
Concept	Serine
Concept	Scattering, Radiation
Concept	Structure-Activity Relationship
Concept	Sulfhydryl Reagents
Concept	Spleen
Concept	Stereoisomerism
Concept	Subcellular Fractions
Concept	Adaptor Proteins, Signal Transducing
Concept	Sucrose
Concept	Mice, 129 Strain
Concept	Blotting, Southern
Concept	Simplexvirus
Concept	Genes, src
Concept	Muscle Fibers, Skeletal
Concept	Insulin Receptor Substrate Proteins
Concept	RNA, Small Interfering
Concept	Nitric Oxide Synthase Type III
Concept	Protein Stability
Concept	Acute Chest Syndrome
Concept	Anemia, Sickle Cell
Concept	Cell Survival
Concept	Follow-Up Studies
Concept	Heart Conduction System
Concept	Mice, Mutant Strains
Concept	Organ Specificity
Concept	Prospective Studies
Concept	Staining and Labeling
Concept	Surface Properties
Concept	Signal Transduction
Concept	Intracellular Space
Concept	Macromolecular Substances
Academic Article	Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle.
Academic Article	Multiple connexins colocalize in canine ventricular myocyte gap junctions.
Academic Article	Connexin expression in the developing avian cardiovascular system.
Academic Article	Gap junction protein phenotypes of the human heart and conduction system.
Academic Article	Multiple connexins confer distinct regulatory and conductance properties of gap junctions in developing heart.
Academic Article	The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195.
Academic Article	Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes.
Academic Article	Differential expression of gap junction connexins in endocrine and exocrine glands.
Academic Article	Structural and molecular determinants of intercellular coupling in cardiac myocytes.
Academic Article	Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction.
Academic Article	The gap-junction protein connexin 56 is phosphorylated in the intracellular loop and the carboxy-terminal region.
Academic Article	Two-dimensional coupling by gap junctions in cultured gastric smooth muscle monolayers.
Academic Article	Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37.
Academic Article	Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes.
Academic Article	Rapid turnover of connexin43 in the adult rat heart.
Academic Article	Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
Academic Article	Cloning and functional expression of a novel gap junction channel from the retina of Danio aquipinnatus.
Academic Article	Expression of zebrafish connexin43.4 in the notochord and tail bud of wild-type and mutant no tail embryos.
Academic Article	Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells.
Academic Article	Mouse connexin40: gene structure and promoter analysis.
Academic Article	Differential expression of gap junction proteins in the canine sinus node.
Academic Article	Functional expression and biophysical properties of polymorphic variants of the human gap junction protein connexin37.
Academic Article	Heteromeric connexons formed by the lens connexins, connexin43 and connexin56.
Academic Article	Heterogeneous localization of connexin40 in the renal vasculature.
Academic Article	Connexin46 mutations linked to congenital cataract show loss of gap junction channel function.
Academic Article	Mouse connexin37: gene structure and promoter analysis.
Academic Article	Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation development.
Academic Article	Gap junction messenger RNA expression by vascular wall cells.
Academic Article	Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43.
Academic Article	Characterization of gap junction channels in A7r5 vascular smooth muscle cells.
Academic Article	Mouse connexin 45: genomic cloning and exon usage.
Academic Article	Gap junction channels formed by coexpressed connexin40 and connexin43.
Academic Article	PKC isoenzymes in the chicken lens and TPA-induced effects on intercellular communication.
Academic Article	Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages.
Academic Article	Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts.
Academic Article	Cardiac gap junction channels show quantitative differences in selectivity.
Academic Article	Peptide inhibitors of intercellular communication.
Academic Article	In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells.
Academic Article	Molecular cloning of a rat uterine gap junction protein and analysis of gene expression during gestation.
Academic Article	Functional role of the carboxyl terminal domain of human connexin 50 in gap junctional channels.
Academic Article	Gap junction synthesis and degradation as therapeutic targets.
Academic Article	New developments in the gap junction field: report from the 2002 ASCB meeting.
Academic Article	Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions.
Academic Article	A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo- or hetero-oligomerization.
Academic Article	Highly restricted pattern of connexin36 expression in chick somite development.
Academic Article	Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5.
Academic Article	Connexin family of gap junction proteins.
Academic Article	Molecular cloning and developmental expression of two chick embryo gap junction proteins.
Academic Article	N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26.
Academic Article	A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts.
Academic Article	Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis.
Academic Article	Transgenic overexpression of connexin50 induces cataracts.
Academic Article	Oxidative stress, lens gap junctions, and cataracts.
Academic Article	Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells.
Academic Article	Quantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43.
Academic Article	The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation.
Academic Article	A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract.
Academic Article	The N terminus of connexin37 contains an alpha-helix that is required for channel function.
Academic Article	Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50.
Academic Article	An intact connexin N-terminus is required for function but not gap junction formation.
Academic Article	Connexin40 and connexin43 determine gating properties of atrial gap junction channels.
Academic Article	Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure.
Academic Article	Cardiac myocyte interconnections at gap junctions Role in normal and abnormal electrical conduction.
Academic Article	Different domains are critical for oligomerization compatibility of different connexins.
Academic Article	Connexin43: a protein from rat heart homologous to a gap junction protein from liver.
Academic Article	Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer.
Academic Article	Differential expression of three gap junction proteins in developing and mature brain tissues.
Academic Article	Selectivity of connexin-specific gap junctions does not correlate with channel conductance.
Academic Article	A mutant connexin50 with enhanced hemichannel function leads to cell death.
Academic Article	Autophagy: a pathway that contributes to connexin degradation.
Academic Article	Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces.
Academic Article	Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization.
Academic Article	Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function.
Academic Article	Characterization of the gap junction protein connexin56 in the chicken lens by immunofluorescence and immunoblotting.
Academic Article	Reversible inhibition of anion exchange in human erythrocytes by an inorganic disulfonate, tetrathionate.
Academic Article	Expression of the gap junction protein connexin43 in embryonic chick lens: molecular cloning, ultrastructural localization, and post-translational phosphorylation.
Academic Article	Selective dye and ionic permeability of gap junction channels formed by connexin45.
Academic Article	Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells.
Academic Article	Chick connexin-56, a novel lens gap junction protein. Molecular cloning and functional expression.
Academic Article	Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties.
Academic Article	Differential expression of two gap junction proteins in corneal epithelium.
Academic Article	Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle.
Academic Article	Bovine connexin44, a lens gap junction protein: molecular cloning, immunologic characterization, and functional expression.
Academic Article	Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40.
Academic Article	Expression of multiple connexins in cultured neonatal rat ventricular myocytes.
Academic Article	Cardiac myocytes express multiple gap junction proteins.
Academic Article	Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium.
Academic Article	Distribution of gap junctions in dog and rat ventricle studied with a double-label technique.
Academic Article	Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50.
Academic Article	Lectins from chicken tissues are mitogenic for Thy-1 negative murine spleen cells.
Academic Article	Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities.
Academic Article	The molecular basis of anisotropy: role of gap junctions.
Academic Article	Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43.
Academic Article	Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45.
Academic Article	Characterization of the gap junction protein, connexin45.
Academic Article	Expression patterns of mRNAs for the gap junction proteins connexin43 and connexin42 suggest their involvement in chick limb morphogenesis and specification of the arterial vasculature.
Academic Article	Cloning and expression of a Xenopus embryonic gap junction protein.
Academic Article	The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.
Academic Article	Mechanisms for the coordination of intercellular calcium signaling in insulin-secreting cells.
Academic Article	Slow ventricular conduction in mice heterozygous for a connexin43 null mutation.
Academic Article	Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein.
Academic Article	Gap junction proteins exhibit early and specific expression during intramembranous bone formation in the developing chick mandible.
Academic Article	Connexin 43 and connexin 40 gap junctional proteins are present in arteriolar smooth muscle and endothelium in vivo.
Academic Article	Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia.
Academic Article	Expression of different connexin genes in rat uterus during decidualization and at term.
Academic Article	Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication.
Academic Article	Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels.
Academic Article	Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins.
Academic Article	An aberrant sequence in a connexin46 mutant underlies congenital cataracts.
Academic Article	Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues.
Academic Article	Electrical properties of mammalian lens epithelial gap junction channels.
Academic Article	Stereoselective, SH-dependent transfer of lactate in mammalian erythrocytes.
Academic Article	Relationship of the multiple forms of human alpha-D-galactosidase and alpha-D-fucosidase in the normal and in Fabry's disease.
Academic Article	Developmentally regulated lectins from chick muscle, brain, and liver have similar chemical and immunological properties.
Academic Article	Change of isoforms' spectra of alpha-L-fucosidase from human skin fibroblasts in intracellular storage of nonhydrolyzable substances.
Academic Article	Two lactose binding lectins from chicken tissues. Purified lectin from intestine is different from those in liver and muscle.
Academic Article	Discrimination of three parallel pathways of lactate transport in the human erythrocyte membrane by inhibitors and kinetic properties.
Academic Article	Quantitation of two endogenous lactose-inhibitable lectins in embryonic and adult chicken tissues.
Academic Article	Chicken tissue binding sites for a purified chicken lectin.
Academic Article	Differential distribution of voltage-gated potassium channels Kv 1.1-Kv1.6 in the rat retina during development.
Academic Article	c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.
Academic Article	An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract.
Academic Article	A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor.
Award or Honor Receipt	American Society for Clinical Investigation
Award or Honor Receipt	Society for Pediatric Research
Academic Article	Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties.
Academic Article	Roles and regulation of lens epithelial cell connexins.
Academic Article	Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated.
Academic Article	Gap junction protein connexin43 exacerbates lung vascular permeability.
Academic Article	Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation.
Academic Article	c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction.
Academic Article	Successful total correction of complete atrioventricular canal, total anomalous pulmonary venous drainage and unroofed coronary sinus in an infant.
Academic Article	Connexin40 abnormalities and atrial fibrillation in the human heart.
Academic Article	Connexin46fs380 causes progressive cataracts.
Academic Article	Connexin23 deletion does not affect lens transparency.
Academic Article	The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses.
Academic Article	Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins.
Academic Article	Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings.
Academic Article	Gap junction structure: unraveled, but not fully revealed.
Academic Article	Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice.
Academic Article	Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.
Academic Article	Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice.
Academic Article	The E368Q Mutant Allele of GJA8 is Associated with Congenital Cataracts with Intrafamilial Variation in a South Indian Family.
Academic Article	Characterization of a variant of gap junction protein a8 identified in a family with hereditary cataract.
Grant	Institutional Career Development Core (Chapter 1)
Academic Article	The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation.
Academic Article	CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice.
Academic Article	p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency.
Academic Article	Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells.
Academic Article	Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization.
Academic Article	Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease.
Academic Article	Do Connexin Mutants Cause Cataracts by Perturbing Glutathione Levels and Redox Metabolism in the Lens?
Academic Article	Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome.
Academic Article	Insights image for "Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells".
Academic Article	Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation.
Academic Article	Circulating Small Extracellular Vesicles May Contribute to Vaso-Occlusive Crises in Sickle Cell Disease.
Concept	Sequestosome-1 Protein
Concept	S100 Calcium Binding Protein G

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